Frequently Asked Questions

What is the ANX 3.0 test?

The ANX 3.0 test is a 15 minute, 35 second, clinical test (or study) designed to determine the ability of both branches of the autonomic nervous system (ANS) to respond to and relax from a challenge. The two branches that make up the ANS are the sympathetic and parasympathetic (SNS and PSNS, respectively). The challenges are:

  1. deep breathing to challenge the PSNS,
  2. valsalva to challenge the SNS, and
  3. standing from a seated position to challenge both systems. (This is equivalent to a tilt-table challenge, as documented in an NIH study – available upon request.  A tilt-table challenge may also be performed.)
How and why is the ANX 3.0 different from similar technologies/procedures?

ANSAR is the only company with patented technologies that incorporate respiratory activity analysis in with heart rate variability spectral analysis methodology to measure the autonomic nervous system, including the Parasympathetics and Sympathetics.

What are the advantages to using the ANX 3.0?

The ANX 3.0 provides the only real-time, digital, quantitative, non-invasive measure of the individual branches of the autonomic nervous system.

How long does the procedure take?

A study takes approximately 15 minutes to perform.

Who performs the procedure (technician, nurse, physician)?

Qualified ANSAR staff train clinical office personnel in the use of the ANX 3.0 monitor. No previous training is required.  ANSAR will train and certify anyone the Doctor requests, as long as they have patient skills.  We have trained technicians, nurses, and physicians to perform the procedure.  Qualified ANSAR staff train clinical office personnel in the use of the ANX 3.0 monitor.

How applicable is the procedure to specific disease states?

Clinical literature substantiating the efficacy of ANSAR’s ANS testing for individuals with a broad range disease states (ICD-10 codes) is available. ANS testing for other disease states is emerging in the clinical literature.

How much space is needed to perform the procedure?

The ANX 3.0 is smaller than a coffee cart and is easily maneuverable. The cart is placed next to a chair or exam/tilt table and occupies relatively little room. A space of approximately 3' by 5' is all that is needed for patient testing.

Are there any special considerations regarding the use of the device?

There is only one patient indication that disqualifies an individual from being tested: an actively pacing cardiac pacemaker.

Reimbursement and Insurance Coverage

Accepted CPT codes allow physicians to be reimbursed for autonomic nervous system monitoring.

A range of CPT codes are available:

  • 95921 (cardiovagal function) – Reimburses for Parasympathetic monitoring and requires the Time Domain Ratios (E/I Ratio, Valsalva Ratio, and 30:15 Ratio).
  • 95922 (sympathetic adrenergic function) – Reimburses for Sympathetic monitoring and requires at least 5 minutes of positive, head-up tilt and the Time Domain Ratios.
  • 95924 – Reimburses for the combination of 95921 & 95922 when both are performed on the same day and excludes 95921, 95922 & 93040.
  • 95943 – Reimburses for Parasympathetic (95921) and Sympathetic (95922) without requiring positive, head-up tilt or the Time Domain Ratios. Note, this code does not yet have RVUs assigned.

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